RMT8 is a histone methyltransferase that exhibits methylation activity toward histones H2A and H4. Intended Use: Suitable for use in studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications. Test Principle: The PRMT8 Homogeneous BioAssay? Kit is designed to measure PRMT8 activity for screening and profiling applications. PRMT8 is a histone methyltransferase that exhibits methylation activity toward histones H2A and H4. The PRMT8 Homogeneous BioAssay? Kit comes in a convenient AlphaLISA format, with a 384-well plate, biotinylated histone H4 peptide substrate, primary antibody, methylation assay buffer, and purified PRMT8 for 384 enzyme reactions. The key to the PRMT8 Homogeneous BioAssay? Kit is a highly specific antibody that recognizes methylated histone substrate. With this kit, only three simple steps on a microtiter plate are required for methyltransferase detection. First, a sample containing PRMT8 enzyme is incubated with the bioti