A SERM; binds to ERα and ERβ (Kis = 380 and 410 nM, respectively); increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause; upregulates progesterone receptors in vaginal epithelium and stroma; inhibits estrogen response element-induced transactivation in MCF-7 cells