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Description
WNT5A Polyclonal Antibody, Alexa Fluor? 488 Conjugated. ? Target Background: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and
Immunogen
KLH conjugated synthetic peptide derived from human WNT5A. Immunogen Range: 330-380/381