SRY (Sex Determining Region Y)-Box 2 (SOX2) (aa 10-70)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat, human
Isotype
n/a
Format
serum
Size
150 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.Subcellular location: NucleusTissue specificity: Expressed in the brain and retina. A very low level expression is seen in the stomach and lung. Expressed in developing urogenital ridge. Also known as: Transcription factor SOX-2, Sox-2.
Immunogen
A synthetic peptide from aa region of 10-70 of mouse SOX2 conjugated to an immunogenic carrier protein was used as the antigen.