SRY (Sex Determining Region Y)-Box 7 (SOX7) (aa 370-388), (C-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, mouse, rat
Isotype
n/a
Format
immunogen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
SOX7 belongs to SOX gene family and SOX proteins are transcription factors with critical roles in the regulation of diverse developmental processes. This gene is mapped to 8p23.1. SOX7 gene contains at least 2 exons. In cotransfected 293 cells, Sox7 reduced Wnt(see WNT1)/beta-catenin(see CTNNB1)- stimulated transcription. SOX7 is a potent activator of FGF3 transcription. It not only plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium but also blocks further differentiation into blood precursors. And it may be required for the survival of both hematopoietic and endothelial precursors during specification.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SOX7(370-388aa LISVLADATATYYNSYSVS), identical to the related mouse and rat sequences.