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Description
CCR5 Antibody (aa3-30) LS-C187838. Recognizes human CD195, also known as C-C chemokine receptor type 5, CCR5 or C-C CKR-5. CD195 is a 353 amino acid ~37 kD multiple pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, preferentially expressed by a subset of memory Th1 (type 1 helper T) cells. Binds to an epitope within the N-terminal (NT) region of CD195. CD195 acts as a high-affinity receptor for several chemotactic chemokines, including MIP-1 alpha (macrophage inflammatory protein 1 alpha), MIP-1 beta, and RANTES (regulated on activation normal T expressed and secreted protein). CD195 is also a major co-receptor for HIV-1 infection, with variations in the CD195 gene, influencing the rate of progression into AIDS. Is suitable for use in immunocytochemistry on human peripheral blood leucocytes.
Immunogen
Synthetic peptide YQVSSPIYDINYYTSEPCQKINVKQIAA corresponding to amino acids 3-30 within the N-terminal region of human CD195. Percent identity by BLAST analysis: Human (100%); Chimpanzee, Monkey (96%); Orangutan, Baboon (93%).