Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rbeta1 receptor, but not IL-12Rbeta2. IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naive T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-gamma production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases. Sample Types: cell culture, citrate plasma, serum. Sample Size: 50 μL. Range: 31.3 - 2,000 pg/mL. Sensitivity: 16.0 pg/mL. Time: 4hr 10min
Size
96 wells
Concentration
n/a
Applications
Immunoassays. Research Use Only. Not for Use in Diagnostic Procedures.