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Description
Ack1 (Tyr284) Polyclonal Antibody, Alexa Fluor? 594 Conjugated. ? Target Background: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR,
Immunogen
KLH conjugated synthetic phosphopeptide derived from mouse Ack1 around the phosphorylation site of Tyr284. Immunogen Range: 260-310/1055