Neuregulin 1-beta (NRG1) is one of many isoforms of NRG that contains a soluble EGF-like domain. Alpha and beta varients are distinguished by difference in length at the C terminus. The EGF-like domain signals through receptors ErbB2, ErbB3, and ErbB4 to act as a growth factor. NRG isoforms are particularly important for nervous system and cardiovasucular development. Sample Type: Serum and plasma Intended Use: The kit is a sandwich enzyme immunoassay for the in vitro quantitative measurement of NRG1-beta1 in human serum, plasma; and other biological fluids not being tested. Sensitivity: 200pg/ml Range: 937.5-60,000pg/ml Specificity: This assay has high sensitivity and excellent specificity for detection of human NRG1-beta1 Precision: Intra CV<10%; Inter CV <15% Test Principle: This assay employs the fast quantitative sandwich enzyme immunoassay technique. Antibody specific for NRG1-beta1 has been pre-coated onto a microplate. Standards, samples and human NRG1-beta1 mix are pipetted in