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Description
Recombinant Human Anti-PCSK9 Antibody (1D05). Recombinant Human Antibody (1D05) is capable of binding to PCSK9, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PCSK9 mAb and CH1-3 region of human IgG2 and a light chain (LC) encoding VL from anti-PCSK9 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. 1D05-IgG2 dose-dependently inhibited PCSK9/LDLr binding in an in vitro TR-FRET assay with an IC50 of 3. 7 ± 0. 1 nM (n = 3).Can be useful in applications such as: Enzyme-linked Immunosorbent Assay, Western Blot, Neutralization
Immunogen
Human proprotein convertase subtilisin/kexin type 9