Purity ~95% (SDS-PAGE). Glycine N-methyltransferase, also known as GNMT, catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. This protein affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and participates in the detoxification pathway in liver cells. Also it is reported that GNMT expression is diminished in human hepatocellular carcinoma (HCC). Recombinant human GNMT protein, fused to His-Tag at N-terminal, expressed in E. coli and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa1-295 of human GNMT, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~34.9kD (315aa), Confirmed by MALDI-TOF Endotoxin: <1EU/1ug (determined by LAL method) AA