An angiogenesis inhibitor with anticancer activity; inhibits bFGF- and VEGF-stimulated HUVEC proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively); inhibits bFGF- and VEGF-stimulated tube formation of HUVECs (IC50s = 0.2 and 0.24 μg/ml, respectively); selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs; reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model at 200 and 400 mg/kg; reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models; completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models; inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models,
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
E-7820 ER 68203-00 ER68203 ER6820300 α-2 CD-31 KP1 320-DM anti-cancer