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Description
The antibody detects a 160 kDa band corresponding to ROCK-I in mouse kidney, rat PC12 cells, and human Jurkat cells. In addition, the antibody detects the 130 kDa caspase-cleavage product in Jurkat cells treated with camptothecin.
Immunogen
Clone (M272) was generated from a recombinant protein that included amino acids near the RhoA binding reigon of human ROCK-I. This sequence has high homology to rat and mouse ROCK-I, and has 50% homology to ROCK-II.