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Description
Alexa Fluor? 647 anti-mouse Notch 3. The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.
Immunogen
Notch 3-Fc fusion protein
Other Names
Neurogenic locus notch homolog protein 3, Notch-3, Notch3, CADASIL, CASIL