Purity > 90% as determined by SDS-PAGE. MW: 23.7kDa. Partial: 22-196. N-terminal 6xHis-tagged. Mus musculus (Mouse). Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
IL-23 subunit alpha; IL-23-A; Alternative name (s); Interleukin-23 subunit p19; IL-23p19