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Description
The monoclonal antibody 31 reacts specifically with secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease (ALP)). SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs and by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV). The reactivity of the antibody 31 with isolated domains of SLPI was evaluated using domains obtained by cleavage using partial acidic hydrolysis. Due to this fact the monoclonal antibody 31 recognizes other SLPI cleavage products.
Immunogen
SLPI purified from sputum
Other Names
Human seminal plasma inhibitor I (HUSI-I), cervix uterine secretion inhibitor (CUSI), bronchial inhibitor (BI), antileukoprotease (ALP) and mucous proteinase inhibitor (MPI).