Kv Channel Interacting Protein 3, Calsenilin (KCNIP3) (aa 1-16), (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
immunogen affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium(Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN(1-16aa MQPAKEVTKASDGSLL).