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Description
BTRC Polyclonal Antibody. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NF
Immunogen
n/a
Other Names
BTRC;BTRCP; FBW1A; FBXW1A; F-box/WD repeat-containing protein 1A; F-box/WD repeat-containing protein 1A; E3RSIkappaB; F-box/WD repeat-containing protein 1A; Epididymis tissue protein Li 2a; F-box/WD repeat-containing protein 1A; F-box and WD repeats prote