N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 52 nM. It is about 1,300 times less potent as an inhibitor of ovine COX-1.{8243} However, N-3PyIA does not distinguish between ovine COX-1 and -2. The IC50 values for ovine COX-1 and -2 are 75 and 50 μM, respectively.{8513}