Immunocytochemistry: 1:20-1:100, Immunofluorescence: 1:20-1:100, Western Blot: 2-4 μg/mL
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Description
PUMA Polyclonal Antibody. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Immunogen
n/a
Other Names
p53 Upregulated Modulator of Apoptosis, Bcl-2 binding component 3, JFY-1