Immunohistochemistry (Paraffin): 1:100-1:1000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:500-1:3000
Reviews / Ratings
If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
PUMA Polyclonal Antibody. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Immunogen
n/a
Other Names
JFY-1, JFY1, bcl-2-binding component 3, p53 up-regulated modulator of apoptosis