Perfringolysin O, Recombinant, Clostridium Perfringens, aa29-500, His-Tag (PFO)
Description
Purity ~85% (SDS-PAGE). Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation. Source: Recombinant protein corresponding to aa29-500 from Clostridium perfringens PFO, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~67.92kD AA