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Description
NCAM / CD56 Antibody (clone MOC-1) LS-C134863. Specificity: MOC-1 detects an isoform of the neural cell adhesion molecule (NCAM) expressed on natural killer (NK) cells of approximately 145 kD. NK cells make up approximately 10%-25% of peripheral blood lymphocytes, In addition, NCAM is expressed on a variety of neural tissues and some tumors of neuron-endocrine origin, such as small cell lung cancer (SCLC). The CD56 antigen is not expressed on other immune cells. NK cells form a distinct subpopulation of lymphocytes, which are capable of performing their cytotoxic activity without MHC restriction. Target cells may include virally infected cells or transformed cells and CD56 appears to be involved in the cytotoxic activity of NK cells. Certain subtypes of T cell lymphomas may express the CD56 antigen. These include peripheral T cell lymphoma (NK cell lymphoma: CD56+, EBV+) and T lymphocytic lymphoma (CD56+/-).