Purity >95%. Proteins can be modified post-translationally by the addition of O -linked N-acetylglucosamine (O -GlcNAc). Nuclear cytoplasmic O -GlcNAcase and acetyltransferase (NCOAT) is a Beta-N-acetylglucosaminidase that removes GlcNAc from O -glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.