MHC Class I Polypeptide-Related Sequence A (MICA) (C-Term), (AA 24-308) protein
Description
Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Glu24-Gln308) of Human MICA fused with a polyhistidine tag at the C-terminus. MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with β-2-microglobulin. MICA shares 85 % AA identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for γ δ T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.