2-89aa; Full Length. MW: 26.16kD. Purity >90% as determined by SDS-PAGE. S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the t
Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage.Lagasse E., Weissman I.L.Blood 79:1907-1915(1992) Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10.Lackmann M., Rajasekariah P., Iismaa S.E., Jones G., Cornish C.J., Hu S., Simpson R.J., Moritz R.L., Geczy C.L.J. Immunol. 150:2981-2991(1993) Molecular characterisation of the genomic locus of the mouse MRP8 gene.Nacken W.K.F., Manitz M.P., Sorg C