產(chǎn)品名稱 FRAX 486 from TOCRIS BIOSCIENCE
    產(chǎn)品貨號 5190/50
    產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
    產(chǎn)品規(guī)格 50 mg
    產(chǎn)品品牌 TOCRIS BIOSCIENCE
    產(chǎn)品概述
    產(chǎn)品詳情
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    Product NameFRAX 486
    DescriptionPotent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable. Purity 98%. MW (observed): 513.39
    Size50 mg
    Concentrationn/a
    Applicationsn/a
    Other Names6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
    Gene, Accession, CAS #CAS: 1232030-35-1
    Catalog #5190/50
    Price
    Order / More InfoFRAX 486 from TOCRIS BIOSCIENCE
    Product Specific ReferencesPubMed: 27071060
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