Purity ≥95%. MW: 192.08. L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
disodium;(2S)-2-hydroxypentanedioate, Sodium (S)-2-hydroxypentanedioate, Disodium (S)-2-hydroxyglutarate, (S)-2-Hydroxypentanedioic acid disodium salt