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Description
APC-AAT complexes Monoclonal Antibody (7). The neoepitope is conformation-dependent and expressed in activated protein C upon complex-formation with α1-antitrypsin. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, of which &al