STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease. Purity 98%. MW (observed): 279.34
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea. endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, Mediator of IRF3 activation, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, Stimulator of interferon genes protein, sting, STINGhSTING, TMEM173, transmembrane protein 173