Linoleic acid is an essential fatty acid and one of the most abundant PUFAs in the Western diet. Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis.{2418,1017} Linoleic acid is metabolized by 15-LO in both plants and animals to form (±)9- and (±)13-HODE (Item Nos. 38400 and 38600).{770}