A selective, non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively); inhibits the contraction of rabbit aorta and rat ileum induced by des-Arg9-BK ex vivo; reduces tissue damage and neutrophil accumulation in a rat model of splanchnic artery occlusion/reperfusion-induced intestinal injury; inhibits des-Arg9-BK-induced paw edema in mice at 3 and 10 mg/kg; reduces fibrosis in a unilateral ureteral obstruction mouse model of kidney fibrosis; reduces mean arterial blood pressure in two rat models of hypertension; reduces plasma glucose and insulin levels in a glucose-fed rat model of insulin resistance; exhibits analgesic properties in several rodent models of hyperalgesia