A potent activator of SUR2-Kir6 and KATP channels; activates SUR2-Kir6 channels (EC50 = 45 nM for SUR2B-Kir6 channel activation); highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay); increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo; reduces infarct size in isolated rabbit hearts via activation of mitochondrial KATP channels (EC50s = 60-90 nM)