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Description
Rabbit IgG polyclonal antibody for Ectodysplasin-A(EDA) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. Anhidrotic ectodermal dysplasia(EDA) is an X-linked recessive disorder which affects ectodermal structures. Ectodysplasin-A, the protein encoded by the EDA gene, is a member of the tumor necrosis factor ligand superfamily that forms a collagen triple helix, suggesting functions in signal transduction and cell adhesion. Wnt signaling does control EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human EDA(254-269aa HLQGQGSAIQVKNDLS), identical to the related mouse and rat sequences.