SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (Internal Region)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human, rat, mouse
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.Subcellular location: Cytoplasm. Cell junction ?? synapse. Cell junction ?? synapse ?? postsynaptic cell membrane ?? postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.Tissue specificity: Widely expressed in brain. Also known as: SH3 and multiple ankyrin repeat domains protein 3, ProSAP2, Proline rich synapse associated protein 2, PSAP2.
Immunogen
A synthetic peptide from the internal region of human SHANK3 (SH3 and multiple ankyrin repeat domains protein 3, ProSAP2) conjugated to an immunogenic carrier protein was used as the antigen.