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Description
Legumain Polyclonal Antibody, Alexa Fluor? 750 Conjugated. ? Target Background: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Immunogen
KLH conjugated synthetic peptide derived from human Legumain. Immunogen Range: 225-275/433