An inhibitor of Nampt and NF-κB pathway activity; potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells lines; inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer xenografts in nude mice at 20-50 mg/kg/day