Purity > 85% as determined by SDS-PAGE. MW: 37.6kDa. Full Length: 1-286aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly (A) site and behind the elongating RNAp II