Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)
Description
Purity > 90% as determined by SDS-PAGE. MW: 67.7kDa. Full Length: 1-351aa. N-terminal GST-tagged. Homo sapiens (Human). Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein