PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the ``remodeling'' and 'de novo' pathways.{939} It is a potent mediator of neutrophil migration,{1437} and the production of reactive oxygen species, and IL-6 in human macrophages.{367,2296} It is a more potent mediator of platelet aggregation than PAF C-18.{3786} Pathological processes involving PAF include necrotizing enterocolitis,{5841} inflammation, asthma, and allergy.{303}