Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
Secreted frizzled-related protein 1;FRP-1;sFRP-1;Secreted apoptosis-related protein 2;SARP-2;SFRP1;FRP, FRP1, SARP2; Soluble Frizzled Related Protein-1, Secreted Apoptosis Related Protein-2, SARP-2