Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%. MW (observed): 1242.37.