An inhibitor of p38α MAPK (IC50 = 7.1 nM); selective for p38α over p38β (IC50 = 200 nM), as well as over p38γ/δ, JNK, ERK1, IKKβ, MEKK1, and TAK1 (IC50 = >10 μM for all) but also inhibits CK1δ and CK1ε; inhibits LPS-induced TNF-α release from THP-1 cells (IC50 = 48 nM); LPS-induced TNF-α production by 87.6% in mice at 10 mg/kg; reduces adjuvant-induced paw swelling in a rat model of rheumatoid arthritis at 30 mg/kg; inhibits Wnt3a-induced phosphorylation of hDvl2 in a p38α-independent manner