Abcb4, Recombinant, Mouse, aa352-708, His-Tag (Multidrug Resistance Protein 3)
Description
Purity ~90% (SDS-PAGE). Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into th
Size
10ug, 50ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
ATP-binding cassette sub-family B member 4, Imported Multidrug resistance protein 21, Publication Multidrug resistance protein 3 By similarity, (EC:3.6.3.44) P-glycoprotein 2 By similarity, P-glycoprotein 3 By similarity