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Description
Mouse Anti-DNMT1 Recombinant Antibody (2B5). Provided herein is a Mouse monoclonal antibody, which binds to DNA Methyltransferase 1 (DNMT1). The antibody can be used for immunoassay techniques, such as ELISA, WB. DNMT1 is an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuro
Immunogen
DNMT1 (NP_001370, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The immunogen sequence: MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG
Other Names
DNA Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferase 1; CXXC-Type Zinc Finger Protein 9; DNA Methyltransferase HsaI; DNA MTase HsaI; EC 2.1.1.37; M.HsaI; CXXC9;