Purity ~99%. ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice. Furthermore, ZSTK474 did not show significant toxicity at the doses tested. Solubility: Soluble in DMSO at 20mg/ml; soluble in ethanol at 2.5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Size
50mg
Concentration
n/a
Applications
n/a
Other Names
ZSTK474, Free Base (2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine, ZSTK-474, C510150)