Purity ~95% (SDS-PAGE). The B cell-activating factor from the TNF family (BAFF), is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation.BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), BAFF-R (BR3), and B cell maturation Ag (BCMA). BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice. Source: Recombinant protein corresponding to human BAFF/BLYS expressed in CHO cells. Molecular Weight: ~18kD Biological Activity: The ED50 was determined by a cell proliferation assay using anti-IgM stimulated murine B cells, and is ≤2ng/ml. Specific Activity: 5x10e5IU/mg. Endotoxin: <1EU/ug (LAL)
Size
50ug
Concentration
n/a
Applications
n/a
Other Names
BAFF/BLYS, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 13B, TNFSF13B, TNFSF20, B Lymphocyte Stimulator, BLyS, B-Cell-Activating Factor Belonging To The TNF Family, BAFF, Dendritic Cell-Derived TNF-Like Molecule, TNF- and APOL-Related Leukocyte Expressed Ligand 1, TALL-1, THANK, CD_Antigen=CD257, BLYS, TALL1, ZTNF4)