Human Exosomal Marker Antibody Sampler Kit, BioAssay?
Description
Exosomes are small membrane-bound vesicles that in recent years have emerged as important molecules for inter-cellular communication. Exosomes are produced during both normal and pathophysiological conditions, and cancer cells have been shown to secrete exosomes in greater amounts than normal cells. The exosomal markers contained in this kit are Alix, Annexin V, ICAM-1, CD9, GM130, EpCAM, flotillin, and HSP70. Alix, a cytosolic scaffold protein, regulates many cellular processes including endocytic membrane trafficking, cell adhesion through interactions with ESCRT (endosomal sorting complex required for transport) proteins, endophilins, and CIN85 (Cbl-Interacting protein of 85kD). Annexin V is a ~30kD protein that binds to phospho-lipids in a calcium-dependent manner. All annexins contain a putative PKC binding site, but only annexin V has been identified as an inhibitor of this pathway. Intracellular cell adhesion molecule-1 (CD54 or ICAM-1) is a cell surface glycoprotein that belong