Human Huntingtin Interaction Antibody Sampler Kit, BioAssay?
Description
Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator. Besides its role in mediating adipogenesis and lipid metabolism, PPAR gamma also modulates insulin sensitivity, cell proliferation and inflammation. CtBP1 is able to regulate gene activity through its intrinsic dehydrogenase activity and by interacting with Polycomb Group (PcG) proteins during development. Along with its homologue, CtBP2, it acts as a transcriptional corepressor of zinc-finger homeodomain factor deltaEF1 to regulate a wide range of cellular processes through transrepression mechanisms. The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced interaction between p53 and its negati