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Description
Rabbit IgG polyclonal Picoband? antibody for Complement C7 detection. Tested with WB, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.
Immunogen
E. coli-derived human Complement C7 recombinant protein (Position: R233-D453).